Sodium thiopental (Sodium Pentothal)

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UPAC: 5-ethyl-5-pentan-2-yl-2-sulfanylidene-1,3-diazinane-4,6-dione

Synonyms: Bomathal, Nesdonal, Penthiobarbital, Pentothal, Pentothal Sodico, Sodipental, Thiomebumal, Thionembutal, Thiopental, Thiopental Nycomed, Thiopental Sodium, Thiopentobarbital, Thiopentobarbitone, Thiopentobarbituric acid, Thiopentone, Tiobarbital Braun, Trapanal

CAS#: 71-73-8 (Sodium Salt), 76-75-5 (Free Acid)

Molecular Mass: 264.32 g/mol

Molecular Formula: C11H17N2NaO2S

Form: Liquid

Administration: IV (Intravenous), Oral, Rectal

Storage: Exposure of pharmaceutical products to heat should be minimized. Avoid excessive heat. Protect from freezing. It is recommended that the product be stored at 20-25°C (68-77°F), however, brief excursions are permitted between 15-30°C (59-86°F).

Each Vial contains 500 mg of Thiopental Sodium.

Sodium thiopental, also known as Sodium Pentothal (or Truth Serum) is the sodium salt form of thiopental, an ultrashort-acting barbituric acid derivative, with anesthetic activity.

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What is Sodium Thiopental (Sodium Pentothal) ?

Sodium Thiopental is a barbiturate (bar-BIT-chur-ate) that is controlled intravenously for the enlistment of general sedation or for the creation of complete sedation of brief length. It is additionally utilized for entrancing and for the control of convulsive states. It has been utilized in neurosurgical patients to diminish expanded intracranial weight. It doesn’t create any excitation however has helpless pain relieving and muscle relaxant properties. Little dosages have been demonstrated to be against pain relieving and bring down the torment limit. Thiopental Sodium eases back the movement of your mind and sensory system.

Utilization:

1. Sedation

Sodium thiopental is a super short-acting barbiturate and has been utilized usually in the acceptance period of general sedation. Its utilization has been generally supplanted with that of propofol, however holds notoriety as an acceptance specialist for fast succession intubation and in obstetrics.

In veterinary medication, sodium thiopental is utilized to incite sedation in creatures. Since it is rearranged to fat, certain slender types of canines, for example, sight dogs will have drawn out recuperations from sodium thiopental because of their absence of muscle versus fat and their fit weight. Then again, large creatures will have fast recuperations, yet it will be some time before it is totally taken out (used) from their bodies.

2. Restoratively instigated trance like state

Notwithstanding sedation acceptance, sodium thiopental was generally used to initiate clinical trance states. It has now been supplanted by medications, for example, propofol in light of the fact that their belongings wear off more rapidly than thiopental. Patients with mind expanding, causing height of intracranial weight, either optional to injury or following medical procedure, may profit by this medication.

3. Status epilepticus

In headstrong status epilepticus, thiopental might be utilized to end a seizure.

4. Willful extermination

Sodium thiopental is utilized intravenously for the reasons for killing. In both Belgium and the Netherlands, where dynamic killing is permitted by law, the standard convention suggests sodium thiopental as the ideal operator to prompt unconsciousness, trailed by pancuronium bromide to deaden muscles and quit relaxing.

Intravenous organization is the most solid and fast approach to achieve willful extermination. Demise is brisk. A state of extreme lethargy is first prompted by intravenous organization of 20 mg/kg thiopental sodium (Nesdonal) in a little volume (10 ml physiological saline). At that point, a triple portion of a non-depolarizing neuromuscular obstructing drug is given, for example, 20 mg pancuronium bromide (Pavulon) or 20 mg vecuronium bromide (Norcuron). The muscle relaxant ought to be offered intravenously to guarantee ideal accessibility however pancuronium bromide might be controlled intramuscularly at an expanded dose level of 40 mg.

5. Deadly infusion

Alongside pancuronium bromide and potassium chloride, thiopental is utilized in 34 conditions of the United States to execute detainees by deadly infusion. A huge portion is given to guarantee fast loss of cognizance. Despite the fact that demise typically happens inside ten minutes of the start of the infusion cycle, some have been known to take longer.

6. Truth serum

Thiopental (Pentothal) is as yet utilized in certain spots as a reality serum to debilitate the determination of a subject and make them more agreeable to pressure.[19] The barbiturates as a class decline higher cortical mind working. A few therapists speculate that since lying is more mind boggling than coming clean, concealment of the higher cortical capacities may prompt the revealing of reality. The medication will in general make subjects talkative and agreeable with investigators; notwithstanding, the dependability of admissions made under thiopental is flawed.

7. Psychiatry

Specialists have utilized Sodium thiopental (Sodium Pentothal) to desensitize patients with fears, and to “encourage the review of excruciating quelled recollections”.

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